الفهرس 
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Abstract
4-Aryl-1(2H)-phthalazinones attracted our attention due to its fame in
constructions of various compounds with highly interesting
pharmacological properties with clinical applications and have
applications as new materials which used as switchable materials, sensors
and inhibitors of metal corrosion.
The present work dealt with study the nitration reaction of 4-aryl-1(2H)-
phthalazinone derivatives under different conditions
We are successful, for the first time, introduced the nitro group into the
aryl group attached to C-4 of different phthalazinone derivatives through
simple nitration reactions with good to excellent yields.
The results showed that the most suitable catalyst was P2O5 at room
temperature to introduce nitro group into the aryl group attached to C-4 of
phthalazinone derivatives 1, 3-10, to form nitro phthalazinones 2, 13-20.
In contrast, 4-halophenyl phthalazinone 11 and 12 derivatives gave a high
yield of mono-nitrated products 21 and 22 using H2SO4 catalyst
(scheme1).