الفهرس 
Title : Role of 6-aminonicotinamide in aluminum phosphide poisoning induced experimentally in rats
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Abstract
Background: Aluminum Phosphide poisoning became one of the most popular suicidal method among young adults with very high mortality rates encroaching 100%. No Antidote has been discovered yet and the only way to save the patient is to be on supportive measures that mostly fail to protect the patient. 6-aminonicotinamide has been proposed to be a possible antidote in the view of many case reports suggesting higher survival rates in patients with G6PD deficiency. Methods: Preclinical study was done on 48 male albino rats for a duration of 24 hours. Aluminum Phosphide poisoning (ALP) was induced by single dose of 15 mg/kg of ALP in 1 mL of corn oil orally by gastric gavage. 30 minutes after the induction of ALP poisoning, rats were treated with either 10% Dimethyl sulfoxide (DMSO) alone with single intraperitoneal dose of 1ml/kg or N-Acetylcysteine (N-AC) alone in dose of single intraperitoneal dose of 200 mg/kg or treated with single intraperitoneal dose of 1 mg/kg of 6-aminonicotinamide (6-AN) dissolved in 10% DMSO. Echocardiography was done for 2-hour duration with readings of systolic Blood pressure and Heart rate in the 30th, 60th, 90th and the 120th minute. Blood samples were collected 1 hour after the induction of poisoning to estimate levels of Malondialdehyde (MDA), Reduced glutathione (GSH) and liver enzymes (AST and ALT). Pathological specimens were collected after death or sacrificing the rats of liver, lung and heart. Rats were observed for 24-hour duration for the estimation of survival rate and time