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Abstract New electrochemical sensors were fabricated based on modification of glassy carbon electrode surface (GC) with consecutive layers of multi-walled carbon nanotubes (CNT), ionic liquid crystal (ILC), graphene (RGO) and manganese dioxide (MnO2) or crown ether (CW); (GC/CNT/ILC/RGO/MnO2) and (GC/CNT/ILC/RGO/CW). Each component possesses a unique feature that contributes to the remarkable electro-catalytic activity of the modified electrode toward the studied compounds. The GC/CNT/ILC/RGO/MnO2 sensor showed excellent current response for simultaneous electrochemical analysis of the three antiviral drugs: Sofosbuvir (SOF); Ledipasvir (LED) and acyclovir (ACY). Also, the electro-oxidation of quaternary mixture of ascorbic acid (AA), dobutamine (DB), acetaminophen (APAP) and amlodipine (AM) to four well-separated peaks successfully was achieved using the GC/CNT/ILC/RGO/CW sensor. The compact conducting surface of (CNT/ILC/RGO) with large surface area allowed the electrodeposition of crown ethers which forms stable host-guest inclusion complexes with the studied compounds. In addition, two other sensors were prepared by modification of GC surface with a mixture of CNT-ILC and cobalt nanoparticles (Co) or CW; GC/(CNT-ILC)/Co and GC/(CNT-ILC)/CW. The GC/(CNT-ILC)/Co was used for the electro-oxidation of three new anti-hepatitis C drugs: Daclatasvir (DAC); SOF and LED and applied for the simultaneous determination of LED with SOF in presence of interfering compounds. The GC/(CNT-ILC)/CW sensor exhibited excellent electro-catalytic activity toward the determination of serotonin (ST). Furthermore, CW is introduced for the first time as an excellent receptor for chiral recognition of tyrosine (TY) enantiomers (L-TY and D-TY) due to its perfect host-guest size matching principle |