الفهرس 
Comparative study of the chemopreventive potential of sulindac and/or fluoxetine with certain natural products during the early stages of colonic carcinogenesis induced in rat
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Abstract
Colon cancer represents the third principal cause of cancer related death all over the world. It is a multistep process that can be activated by any of various environmental carcinogens. Recent studies suggest that combinatorial chemoprevention could be a better approach for prevention of carcinogenesis. It seems probable that a combination of phytochemical ingredients with other agents could impart enhanced effect against cancer. Therefore, two of natural polyphenol compounds namely, kaempferol (KMP) and epigallocatechin-gallate (EGCG) were utilized in the present study. Sulindac (SL), a non- steroidal anti-inflammatory drug, and the antidepressant fluoxetine (FLX) are considered as potentially valuable chemopreventive agents against colon carcinogenesis. Therefore, an animal model of dimethylhydrazine (DMH)-induced preneoplastic lesion was established by subcutaneous injection of 30 mg/kg body weight once a week for 6 weeks. Subsequent comparison of the effects of pre-treatment with SL (20 mg/kg body weight) or FLX (30 mg/kg body weight) as single pre-treatment or in combination with either KMP in a dose of 200 mg/kg, or EGCG (0.01% aqueous solution). All pre-treatments were given daily for 6 weeks. Adult male Sprague-Dawely rats were randomly assigned into 13 groups, the first four groups served as control groups either non- treated or receiving the vehicles saline, CMC, and EDTA. For comparing the chemopreventive potential of the utilized agents either as single or combined regimens, the remaining groups were divided according to the pre-administered agent before DMH into, DMH alone, single SL and FLX groups as well as single KMP or EGCG groups. In addition to four other combined treated groups namely; KMP+SL, EGCG+SL, KMP+FLX and EGCG+FLX.