الفهرس 
Possible modulation of neurochemical and behavioral alterations induced by nicotine-cannabis addiction in rats
AbstractOnly 14 pages are availabe for public view
 |  | from | 228 |  |  |
| | | from | 228 | | |
Abstract
Nicotine (Nic) and cannabis are considered to be the most abused drugs worldwide that are progressively taken concomitantly. The present study aimed to investigate the modulatory effect of Nic on cannabis extract-induced neuro-inflammation, oxidative status, and the associated behavioral/biochemical alterations. Nic (0.25 mg/kg) and/or cannabis extract expressed as x9-tetrahydrocannabinol (THC10/20; 10 and 20 mg/kg) were given intraperitoneally for 30 days to Wistar rats. Furthermore, the purpose of this study was extended to determine whether donepezil (Don; 2.5 mg), an acetylcholinesterase inhibitor, in combination with nicotine (0.5 mg/kg) and/or THC (20 mg/kg) might modulate behavioral and biochemical changes in naïve rats. Nic shortened the floating time in forced swimming test, increased locomotion in the open field test, and decreased escape latency in the Morris water maze when co-administered with THC. On the other hand, Don co-administration exhibited depressive-like behavior but yet, not as much as that revealed by THC20 and reduced ambulation