الفهرس 
Development and In-vivo Evaluation of a Novel Delivery System for Radiopharmaceuticals
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Abstract
Nanotechnology may be applied in medicine where the utilization of nanoparticles ({u2264} 100 nm) for the delivery and targeting of diagnostic and/or therapeutic agents is at the forefront of projects in cancer nano-science. This PhD thesis points a novel one step synthesis approach to build up polyethylene glycol capped silver nanoparticles doped with I-131 radionuclide (1311-doped Ag-PEG NPs) as theranostic probe. It also states the development of a novel technique for fabricating a tumor diagnostic probe based on iron oxide nanoparticles excluding the utilization of chelating ligands.1311-doped Ag-PEG NPs was prepared with average hydrodynamic size 21 nm, zeta potential - 25 mV, radiolabeling yield 98.1 ± 0.81%, and showed good in-vitro stability in saline and mice serum. The in-vitro cytotoxicity study of cold Ag-PEG NPs formula as a drug carrier vehicle showed no cytotoxic effect on normal cells (WI-38 cells) at a concentration below 3 æl/104 cells