الفهرس | Only 14 pages are availabe for public view |
Abstract Aim of this study: was to assess the ability of double antibiotic paste versus calcium hydroxide used as intra-canal medication in reducing pain and level of endotoxins in necrotic teeth with apical periodontitis.Subjects and methods: Thirty-six patients with single rooted necrotic premolars with apical periodontitis were randomly assigned into two groups according to the intra-canal medication used; calcium hydroxide group (CH) and double antibiotic paste group (DAP). Preoperative pain was recorded using numerical rating scale (NRS). After isolation and disinfection, access cavity was performed followed by chemico-mechanical preparation which was done using rotary Race files with 2.5% NaOCl irrigation. Then, intracanal medication was placed for 7 days. Postoperative pain was recorded at 6, 12, 24 and 48 hours postoperatively. Endotoxin samples were collected by paper points before (S1) and after chemico-mechanical preparation (S2), and after 7 days of intra-canal medication (S3). A sandwich ELISA method was used for the quantification of endotoxins |