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العنوان
Probes for some antimicrobials :
الناشر
Marwa Soliman Abdelhamid Elhamshary ,
المؤلف
Marwa Soliman Abdelhamid Elhamshary
هيئة الاعداد
باحث / Marwa Soliman Abdelhamid Elhamshary
مشرف / Samir Elmoghazy
مشرف / Hala Aleasa
مشرف / Marwa Ahmed Fouad
تاريخ النشر
2018
عدد الصفحات
252 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
24/4/2018
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutical Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 301

Abstract

The present thesis describes the investigation of three fluoroquinolones, namely, Norfloxacin, Levofloxacin and Lomefloxacin via three techniques through two main approaches. First, is complexation of the investigated drugs with lanthanides as samarium, terbium and lanthanum and detecting the formed complex whether spectrophotometrically or spectrofluorimetrically.This approach applies the multivariate analysis for the detection of the optimal blend of factors affecting this complexation over two phases to build the model; screening and optimization, followed by verification and validation of the developed models. Second approach is constructing potentiometric sensors for the nominated fluoroquinolones based on tetraphenylborate as ion-exchanger casted with PVC and DOP and plasticizer followed by the study of the performance characteristics of the electrodes