الفهرس 
Title
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Abstract
The present investigation was undertaken to study the biological effects of fish oil (FO) of sardine feeding on protecting experimental of hypercholesterolemic animals and the biological effects on curating as well as lowering hypercholesterolemia , which induced diseases such as coronary heart diseases (CHD), cardiovascular diseases (CVD) and atherosclerosis which are the most common heart diseases. Fish oil was extracted from sardine fish and analysed to know its fatty acids{u2019} content. This extracted oil was used for the present study. Total of 72 male albino rats weighing from 144±6 g were used in the present work. Rats divided into two main groups for two experiments as follows: First experiment: studying the protective effects of fish oil on animals fed on hypercholesterolemia-induced diets (HCD) containing 0, 3, 7 and 10% fish oil. Second experiment: Studying the curative effect of fish oil to decrease the hypercholesterolemia in hypercholesterolemic animals (fed on hypercholesterolemic-diets for 15 days before the second experiment). The feeding experiments continued for three weeks on basal diets containing Lipostat drug as well as other treatment with 0, 3, 7, 10% fish oil. At the end of experiments, the animals were decapitated, then plasma was prepared as well as livers and brains were excised, rinsed and kept frozen at -20C. Total lipids, triglycerides, cholesterol, LDL-c, vLDL-c, HDL-c and glucose, contents as well as AST, ALT and ALP activity were investigated in plasma. In addition to total lipids, triglycerides and cholesterol contents, AST and ALT activities (in liver), and malondialdehyde in liver and brain were measured. The results of the first experiment showed that fish oil prevented the increase of hypercholesterolemia