الفهرس | Only 14 pages are availabe for public view |
Abstract Multiple studies were conducted to show great differences in their results regarding the brain iron deposition. Some studies showed areas in the brain with high iron deposition, but they weren’t in other studies. Our study showed that there was no significant differences in the R2* values of the caudate and thalamic regions (left and right sides) between healthy controls, B-thalassemia and SCD groups, for exception of a moderate significant difference in the left thalamic region (p= 0.021) between the B-thalassemia and healthy control groups. Finally, our study suggested that no brain iron overload occurs in group of patients. This may be attributed to the heavy chelation therapy given to them in our institute that makes cardiac affection rarely occurred. However, more broad studies with larger cohorts are recommended to set international grading system or cut off values for the brain iron content above which iron overload should be considered. |