الفهرس 
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Abstract
This a prospective case control observational study at PICU at Beni-Suef University Hospital from August 2020 till March 2022. The study included 48infant with sepsis and another 30 healthy as a control group. All participations subjected to the following:full history taking, full clinical examination and laboratory investigations as CBC, CRP, blood culture & sensitivity, liver functions, serum creatinine and plasma levels of CD64. Patients group was followed up for manifestations of sepsis, SIRS and sever sepsis. Patients with severe sepsis were assessed by another sample to follow up the plasma level of CD64.
Early diagnosis of sepsis is mandatory for tailoring the treatment and improving the diagnosis, given the necessity for timely initiation of appropriate antibiotics (Kumar A et al., 2006).
A pivotal role in rapid diagnosis is attributed to biomarkers, which are necessary for early diagnosis, monitoring of treatment and evaluation of prognosis of sepsis. The purpose of the current study was to evaluate the diagnostic value and determine the best cut-off levels for nCD64 in early diagnosis in childhood sepsis.
We found that the most frequent cause of admission was pneumonia, and the most common isolated organisms were gram negative organisms mainly Klebsiella. SIRS was reported in (39.58 %) of patients while severe sepsis was reported in (20.8%).
CD64 was significantly higher in cases than controls (p= 0.003) and in patients with SIRs and severe sepsis (p=<0.001, 0.007), respectively.
Also, CD64 significantly increased after development of sepsis in admitted patients. The cutoff value of CD64 >1308(pg/ml) has an AUC of 0.792 and a sensitivity 80% and specificity of 76.9% each for CD64 expression in pediatric sepsis with 95% Confidence interval 0.653 to 0.895.
So in conclusion We can say that Neutrophil CD64 was sensitive for early diagnosis of sepsis Compared to CRP and blood culture.