الفهرس 
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Abstract
Ozone (O3) gas discovered in the mid-nineteenth century is a molecule consisting of three atoms of oxygen in a dynamically unstable structure due to the presence of mesomeric states. Although O3 has dangerous effects, yet researchers believe it has many therapeutic effects. Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Nevertheless, most studies have focused only on their ability to disinfect and treat disease, and have not been investigated for their beneficial effects on healing of the bone after tooth extraction. (15)
Aim of the work: to evaluate histologically and histomorphometricaly the possible effect of ozone therapy on bone healing after tooth extraction in rabbits with alloxan induced diabetes mellitus. Materials and Methods: Thirty adult male New Zealand rabbits weighing 1500-2500 grams (approximately six months of age) will be divided into 3 equal groups: group I;(control group), group II; (diabetic group): diabetes will be induced by a single intravenous injection of alloxan in a dose of 100 mg/kg and group III:(Ozone group) rabbits will be treated as in diabetic group then they will be treated with ozone therapy which will be applied topically in the form of gel inside the tooth socket.. Ten rabbits will be sacrificed after intervals of 1, 6 and 12 weeks. Each sample will be dissected and prepared for histological and histomorphometric evaluation.