الفهرس 
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Abstract
Apelin is a naturally occurring peptide that may interact with the orphan G-protein-coupled Apelin receptor, which was first classified as such.
Pre-pro-Apelin is broken down into 36 to 13 amino acid fragments during proteolysis, with the 12 C-terminal amino acids remaining the same in all Apelin isoforms. Unknown is the precise mechanism behind this proteolysis.
All eukaryotic species may include apelin and its receptor, which are expressed in a wide range of bodily tissues including the brain and heart.
Many biological activities depend on apelin and its associated receptor, which plays a crucial role in cardiovascular regulation.
The system’s beneficial effects have been shown during the treatment of conditions as diverse as hypertension, atherosclerosis, myocardial infarction, and heart failure (HF).
A unique endogenous peptide ligand known as apela/Elabela/Toddler has recently been found to activate the apelin receptor, and it has been shown that this activation is essential for cardiovascular development and function.
Children with heart failure in our research had variations in their blood levels of ANP and Apelin, both of which may be used to gauge the severity of the condition.