الفهرس 
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Abstract
Direct pulp capping (DPC) is a procedure to maintain the pulp vitality using a dental material with specific properties. Mineral trioxide aggregate (MTA) is considered as a gold standard material, however, it has some drawbacks. Several studies were conducted to find a more appropriate material than MTA. In this study, a combination of simvastatin and calcium hydroxide (SIM-CH) was used as a DPC material as it was proved that simvastatin influenced odontoblast cells differentiation.
Objectives: To compare histologically the effect of the combination of SIM-CH to MTA as a DPC material in rabbits’ incisor.
Materials and Methods: 32 sound maxillary incisor teeth of 16 male New Zealand white rabbits were divided into; group I received MTA, and group II received (SIM-CH) as a DPC material. Class V cavities were done in the upper incisor teeth, then DPC materials were applied. Finally, the final restoration was light cure resin modified glass ionomer. The animals were euthanized after 1, 2 weeks. Routine histological preparation was done, then sections were stained by hematoxylin and eosin (H&E). Scoring system was done to evaluate the newly formed dentin. The percentage of the surface area of the newly formed dentin was assisted by histomorphometric analysis.
Results: Both groups showed new dentin formation. group I reported somewhat more continuous layer of tertiary dentin than SIM-CH group with less inflammatory response. on the other hand, the dentin bridge of the SIM-CH group demonstrated more orderly organized tubules. There was a statistically significant difference regarding the histomorphometric analysis of the percentage of the surface area of the newly formed dentin of group I compared with group II (p< 0.05).
Conclusion: SIM-CH could be a remarkable alternative DPC material.