الفهرس 
Type 1 Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Abstract
Background: Insufficient sleep duration and poor sleep quality have been linked with insulin resistance, impaired glucose metabolism and type2 diabetes. However, the effect of sleep disruption on type1 diabetes(T1D) has not been thoroughly explored.
Aim: To study the association between sleep disturbances and glycemic control, insulin resistance and diabetic vascular complications among type 1 diabetic adolescent.
Methodology: Sixty adolescents with T1D were compared to 60 matched controls. Diabetes-duration, insulin-therapy, fundus, and the neuropathy disability score were assessed. Fasting lipid profile, fraction-C of glycosylated hemoglobin (HbA1c) and urinary albumin-excretion were measured with calculation of the insulin sensitivity score (ISS). Overnight polysomnography (PSG) was done with analysis of various sleep parameters.
Results: Insulin sensitivity score was positively correlated with sleep efficiency and negatively correlated with stage 2 sleep and periodic limb movement index (PLMI). HbA1c was positively correlated to sleep onset latency and stage 2 sleep, and negatively correlated to sleep efficiency and rapid eye movement (REM). Diabetic nephropathy was positively correlated to light sleep and negatively correlated to deep sleep. In addition, adolescents with T1D having diabetic neuropathy had significantly longer light sleep and shorter deep sleep with increased arousal index. Sleep efficiency was positively correlated to high-density lipoproteins (HDL) and negatively correlated to low-density lipoproteins (LDL), while REM was negatively correlated to total cholesterol and triglycerides. Arousal index was positively correlated to total cholesterol and negatively correlated to HDL, and the number of awakenings/nights was positively correlated to LDL and triglycerides.
Conclusions: Sleep disorders are associated with impaired glycemic control, insulin resistance and diabetic vascular complications among adolescents with T1D.