الفهرس 
Title : Preparation of novel modified electrodes and their application for selective determination of some drugs using electrochemical methods
ContentsOnly 14 pages are availabe for public view
 |  | from | 78 |  |  |
| | | from | 78 | | |
Abstract
In this work, screen-printed electrodes chemically modified with 3,4-Dihydroxy-9,10-dioxo-2-anthracenesulfonic acid sodium salt [Alizarin Red (ALZ.R)] and Tricresyl phosphate (TCP) as a solvent mediatoras were used as sensitive electrochemical sensors for determination of cyclobenzaprine hydrochloride (CZP.HCl) in pharmaceutical preparations.The sensor showed a stable response for 22 days with reproducible potential over linear concentration range (5.0 x 10⁻⁶ 1.0 x 10⁻² mol L⁻¹) at 25 ± oC with Nernstian slope of 60.12 ± 0.18 mV decade-1 for detection limit of 4.95 x 10{u2013}6 mol L⁻¹. The analytical performance of the screen printed electrode was optimized according to IUPAC guidelines. Electrochemical techniques were proposed in this work. Platinum and platinum{uF02D}nickel nanoparticles supported on graphene [Pt/Gr and Pt-Ni/Gr] was prepared using a simple chemical reduction method depending on the addition of ethylene glycol as a reducing agent. Microwave irradiation helped in the reduction process activation through applying one continuous mode for 50 s. Incorporating nickel together with platinum in Pt-Ni/Gr nanocomposite increased its electrocatalytic activity during cyclobenzaprine HCl oxidation in phosphate buffer solution.The drug concentration was linearly affecting the nanocomposite activity up to 8 mM.Tafel slope and exchange current density values at Pt/Gr and Pt-Ni/Gr nanocomposites were estimated to conclude that better activity was observed at Pt-Ni/Gr. Up on evaluating the nanocomposites activity during storage condition, Pt-Ni/Gr exhibited increased oxidation current density retention percentage value when compared to that at Pt/Gr.These obtained results would elect the as-prepared Pt-Ni/Gr nanocomposite as a suitable active material for estimating cyclobenzaprine HCl