الفهرس 
Title : Production of bacterial levan and its anticancer effect
AbstractOnly 14 pages are availabe for public view
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Abstract
This study aimed to evaluate the cytotoxicity of levan as a natural biopolymer alone and in combination with cisplatin.Consequently, honey isolate NRCA, Pseudomonas aeruginosa, recorded promising levansucrase activity and levan yield. Crude levan (CL) was dialyzed to Dialyzed levan (DL). Crude levan showed cytotoxicity effect against MCF-7 while it had a safe effect on normal cells. Dialyzed levan increased cancer cell viability. Combination treatment of CL and cisplatin significantly reduced the IC50 of cisplatin. Results indicated to the cytostatic role of CL. Accordingly, treatment design to treat spheroids with a combination of both CL and cisplatin at different time intervals was suggested. This design was found to increase the cytotoxicity against MCF-7 spheroids and reduce the cytotoxicity of cisplatin on spheroids of normal cell line