الفهرس | Only 14 pages are availabe for public view |
Abstract Cancer is considered a disease of multiple etiologies and it may require different forms of treatment as chemotherapy, radiotherapy, target therapy or even surgery. Cancer treatment is upon combination mostly of more than one drug that can act simultaneously on different targets. Therefore, the development of different multi- targeting anti-cancer therapies is of an importance nowadays in attempt to increase efficiency of chemotherapeutic agents and reduce adverse events. Tamoxifen (TAM) is a selective estrogen receptor modulator, which is mainly used for treatment of hormonal positive breast cancer.Simvastatin, an HMG-COA reductase inhibitor with impressive antitumor effects on several models of animal tumors and cell lines |