الفهرس 
Study of plasma circulating cell-free dna integrity as a biomarker for diagnosis of patients with HCV-related hepatocellular carcinoma
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Abstract
Background:The clinicalvalue of plasma circulating cell-free DNA (cfDNA) integrity as diagnostic biomarker in the patients withHCV related hepatocellular carcinoma (HCC) was investigated and correlated with the commonly used marker alpha fetoprotein (AFP). HCV related HCC patients had lower plasma cfDNA integrity than those with HCV related liver cirrhosis patients (p value <0.005). Also, there was a statistical significant negative correlation between AFP and plasma cfDNA integrity with r value =0.54 (P value<0.001). The AUCs for detection of HCC by cfDNA integrity and AFP were 0.965(p value < 0.001) and 0.886(P <0.001) respectively.Conclusion: The results of this study suggest that the plasma cfDNA integrity can be used as a potential early marker for HCC among the HCV patients