الفهرس 
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Abstract
• Aim of the work: The present study aimed to study the immunohistochemical expression of ELF3 and E-cadherin in the studied cases of HCC and to evaluate their prognostic significance in relation to the available clinicopathological parameters. • Materials and Methods: This study evaluated 66 selected specimens previously diagnosed as HCC. Tissue specimens were subjected to staining with ordinary H&E staining. In addition, ELF3 and E-cadherin immunohistochemical staining was done with assessment of clinicopathological parameters including age, sex, tumor size and multiplicity, histopathological grading and vascular invasion. • Results: Immunohistochemical analysis showed high ELF3 expression (above the statistically determined cut off point) in 50% of specimens. High ELF3 expression was reported significantly more in cases with old age (> 60 years), multiple tumors, larger tumor size (> 5cm), poorly differentiated tumor grade and vascular invasion. The mean ELF3 staining intensity was higher but not significantly different in male cases compared to female cases. The mean ELF3 staining intensity was significantly higher in cases with multiple versus single tumors, with large (>5) versus small (<5) tumor size, with poorly differentiated versus moderately or well-differentiated tumor and cases with vascular invasion versus cases that did not report invasion. Regarding E-cadherin in the present study, immunohistochemical analysis showed negative E-cadherin expression in (43.9%) of cases. Negative E-cadherin expression was reported significantly more in cases with multiple tumors, larger tumor size (> 5cm), poorly differentiated tumor grade and vascular invasion. Regarding the relation of ELF3 expression to E-cadherin expression in the present study, cases with high ELF3 expression showed significantly more negative E-cadherin expression. Significantly higher ELF3 staining intensity was reported in cases with negative E-cadherin compared to those with positive E-cadherin expression.