الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Vitiligo is the most common depigmenting disorder affecting 0.1%–2% of the population worldwide. The characteristic white patches result from the selective loss of melanocytes. Sustained recent efforts have resulted in a detailed understanding of the genetic architecture of vitiligo. About 80% of vitiligo risk is attributable to genetic factors; and the rest (20%) is attributable to the environment. Over the past decade, substantial progress has been made in our understanding of the pathogenesis of vitiligo.
This study was conducted to detect the PGC1-α gene expression in Vitiligo patients and to investigate the possible role of PGC1-α in the pathogenesis of this disease.
The mean PGC alpha level gene expression in cases was 0.3±0.1 and that for controls was 1.03±0.1. There was a highly statistically significant decrease of PGC alpha level gene expression in cases than controls.
There was a significant role of PGC alpha gene expression in prediction of vitiligo. At a cut off ≤0.78 of PGC alpha gene expression, its sensitivity was 93.3%, specificity 100%, PPV 100% and NPV 93.7%.
The mean age of patients with vitiligo was 30±11 and most of them were males (60%). 13.3% of patients have +ve family history.
Most of the studied patients had skin type 4 (70%) followed by skin type 3 (26.7%). Most of the studied patients had generalized and symmetrical bilateral affection of vitiligo. The mean VIDA score was 2.3±1.4.