الفهرس | Only 14 pages are availabe for public view |
Abstract Psoriasis is one of the most prevalent chronic inflammatory skin diseases causing significant impairment of quality of life, at least to the same extent as other major medical diseases. Psoriasis is a chronic, inflammatory skin disease, characterized by raised, red scaly plaques. This disease affect affects about 2-3% of the world-wide population. Psoriasis is also associated with several comorbidities, suggesting that the underlying pathogenesis of the disease is more than “skin deep”. Psoriasis arises through chronic interactions between hyper-proliferative KCs and infiltrating activated immune cells. Initially, psoriasis as considered solely to be due to dysfunction of limiting KC proliferation. Infiltration of immune cells was noticed, but not considered to be key in pathogenesis, but rather just a consequence of the hyper-proliferating KCs. Over the last 20 years, it has been continuously discussed whether psoriatic skin lesions arise from a primary alteration in epidermal KCs or in dermal immunocytes. Nowadays, it is believed that psoriasis is most likely a Th1/Th17 induced inflammatory disease. LRG has been isolated from human serum in 1977, and is a plasma glycoprotein of 312 amino acids in length and approximately 50 kda glycoprotein, in which 20% of amino acid residues consist of leucine with a periodic pattern of leucine rich repeat. LRG is expressed by liver cells, neutrophils, endothelial cells and macrophages. LRG expression is upregulated during early neutrophil differentiation and is increased in response to acute phase mediatory such as IL-6, TNF-α and IL-1β. Although LRG is thought to be associated with bacterial infection, immunological diseases and several types of cancer, the precise function of LRG still remained unknown. Recent study showed that serum levels of LRG were significantly higher in patients with autoimmune diseases such as RA, Crohn’s disease, Behçet disease and ulcerative colitis. The current study was conducted on 30 psoriatic patients whose age ranged from 20 to 53 years. The diagnosis of psoriasis was based on a thorough physical examination and detailed history taking. The clinical grade of psoriasis was assessed using the ‘‘classic’' PASI. Thirty healthy subjects who had no systemic or dermatological diseases of matching age and sex served as control. Three ml blood sample was taken for detection of serum levels of LRG using ELISA kits. Our results revealed statistical significant difference in LRG levels between control and patient groups with higher values in patient group. While there was no statistically significant difference in LRG levels among patients as regards disease severity degrees. On the other hand there was no statistically significant in patient group compared to control group as regards age, sex, smoking and Body Mass Index. Also our resuts revealed that there was no statistically significant difference in PASI severity in patient group as regards patient age, sex, family history, BMI, smoking, duration(years) of psoriasis. Also our study detected that there was no statistically significant difference between PASI severity and LRG (pg/ml) in patient group. There was no statistically significant difference in PASI score in patient group as regards patient sex, family history and smoking. There was no statistically significant correlation between PASI score and any of age, duration (years), BMI or LRG(pg/ml) among cases. Also the results revealed that there was statistically significant positive correlation between LRG level and BMI which indicates that increasing in BMI will be associated with increasing in LRG (pg/ml) level among cases. On the other hand there was no statistically significant correlation between LRG (pg/ml) level and any of age, duration or PASI among cases. There was no statistically significant difference in LRG level in patient group as regards patient sex, family history, smoking and PASI severity. In conclusion, increased serum levels of LRG in psoriatic patients compared to controls pay attention to their possible role in the pathogenesis of psoriasis. a potential role for neutrophils in modulating the microenvironment through the release of LRG1 from activated neutrophils. Also BMI has been supposed to be a prog-nostic factor for the response to treatment in psoriasis. |