الفهرس 
Evaluation of survival of mature second premolar teeth with periapical lesion following different regenerative treatment protocols (Randomized controlled trial)
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Abstract
This study aimed to compare the survival of necrotic mature second premolars with periapical lesion following treatment with two different regenerative protocols, PRP versus PRF pulp regeneration. Both regenerative endodontic procedures were used for regeneration of pulp tissue in the pulpchamber as well as the root canal. Materials and Methods Twenty-eight patients with twenty-eight mature necrotic second premolarswith periapical lesion were selected from the outpatient clinic of endodonticdepartment, Cairo University. An approval from the ethic committee and aninformed consent from the patients were taken. Patients were randomly divided into two groups Comparator Group: PRP (number of teeth=14) Intervention Group: PRF (number of teeth=14) After the administration of the local anesthesia and rubber dam isolation,access cavity was opened. Cleaning and shaping process started withconfirmation of apical patency, and working length was determined using an apexlocator and reconfirmed using radiograph. Mechanical instrumentation was doneusing rotary M-pro system according to manufacturer{u2019}s instruction. Further apicalpreparation was done if needed using manual K-files. Irrigation was done withtotal volume of 20 mL of 2% sodium hypochlorite, and 17% EDTA as a finalflush. An inter-appointment medication of bimix antibiotic paste was for 2 weeks. In the second visit, Biodentin was used to build up the tooth, then accesscavity was re-opened, followed by preparation of a circumferential step at thelevel of pulp horns, this step acted as a support for collagen plug, whichacts as a barrier between platelet concentrates and biodentin restoration. Platelet concentrates was prepared by obtaining venous blood by venipuncture of theantecubital vein, then centrifugation of the sample as to obtain PRP and PRF. Kfile#15 was introduced beyond the apex as to allow for bleeding, then PRP andPRF was introduced inside the canals. A collagen plug was placed over the PRclot and access cavity was restored with biodentin. Results The outcome measures were evaluated clinically and radiographicallythroughout follow up periods including; tooth survival, healing of periapicallesion, regeneration of pulp tissue in pulp chamber, and sensibility. Toothsurvival was tested clinically after 1 year showing survival rate for both groups