الفهرس 
Application of advanced analytical techniques of the determination of drugs acting on histamine receptors
AbstractOnly 14 pages are availabe for public view
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Abstract
In this thesis, simple, fast and sensitive methods of analysis were developed for the determination of some drugs acting on histamine receptors either alone, in combination with other drugs or in the presence of some related substances in their pure form, commercially used pharmaceutical forms and in human plasma and urine. Antihistaminic dugs cited in this thesis are H1 antagonists (Desloratadine and Levocetirizine dihydrochloride and H2 antagonists (Famotidine, Nizatidine and Ranitidine). A reversed phase high performance liquid chromatography (RP-HPLC/UV) was developed and validated for the simultaneous determination of some H1 antihistaminic drugs including Desloratadine and Levocetirizine dihydrochloride in combination with other drugs including Ambroxol hydrochloride, Guaifenesin, Paracetamol, Phenylephrine hydrochloride and Pseudoephedrine hydrochloride. Also, Experimental design approach for the development and validation of a RP-HPLC method for the simultaneous determination of some H2 antihistaminic drugs including Ranitidine in the presence of one of its main impurities which is ranitidine related compound A (5-[[2-aminoethyl)thio]methyl]-N,N-dimethyl-2-furan methamine, hemifumarate salt), Nizatidine and Famotidine TLC-densitometric method was described for the simultaneous determination of Ambroxol, Pseudoephedrine hydrochloride and Desloratadine. Potentiometric determination of Levocetirizine dihydrochloride was applied using modified carbon paste sensor. These methods were validated and statistical comparison was carried out between the results of the proposed methods and those of the official or reported methods and there was no significant difference in terms of accuracy and precision