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Abstract Imaging of patients with palpable masses after breast surgery is challenging as morphological criteria of post-operative changes may overlap with those of recurrent breast cancer. Dynamic contrast enhanced MRI represent the most sensitive imaging technique in evaluation of post-operative breast however, it lacks such high specificity. DTI represent a modified diffusion technique that is considered a promising tool in characterization of breast lesions. DTI parameters can be used as a complementary tool to dynamic contrast enhanced MRI to increase its specificity especially in challenging cases such as cases who underwent previous breast surgery. The main finding of this study is that DTI parameters can increase sensitivity, specificity and accuracy of dynamic contrast enhanced MRI in predicting recurrent breast cancer. Overall, malignancies exhibited lower MD, AD, and RD, and higher FA and RA values when compared to their values in benign lesions. Among the DTI parameters, MD contributed most significantly to the overall diagnostic performance. Regarding accuracy, our study revealed that MD showed the highest accuracy (92.2%) in discriminating recurrent breast cancer from post-operative changes compared with other DTI parameters (80.5% for FA, 84.4% for AD, 80.5% for RD, and 59.7% for RA). |