الفهرس 
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Abstract
Background: Multiple sclerosis (MS) is the most common autoimmune disease affecting the central nervous system (CNS), it is a demyelinating disease of the central nervous system, which leads to impaired cognitive, motor and or sensory functions. Aim: The study aimed to assess health related quality of life among patients with multiple sclerosis at Minia University Hospital. Design: Descriptive research design was used. Sample: A purposive sample consists of 60 patients with multiple sclerosis. Settings: The present study was conducted at out patients neuropsychiatric clinic at Minia university hospital. Tools: an interview structured interviewing questionnaire was usedwhich included; the first tool: Personal Data; the second tool: Multiple Sclerosis Quality of Life(MSQOL). Results: The mean age of patients was 33 ± 7.7 years old and about two-thirds of them were females, also, about half of pateints has fair quality of life. There was highly statistically significant difference between overall quality scores among studied patients and physical health, role limitations due to physical problems, role limitations due to emotional problems, pain , emotional well-being , energy, social function, cognitive function and health distress. Conclusion: health related quality of life decreased among half of the studied multiple sclerosis patients and not influenced by their demographic characteristics. Recommendations: community health nurse provide health education, continuous health assessment and observation to the multiple sclerosis patients (health status, emotional status, skin integrity, pain sensation, balance and movement ability).