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Abstract CDC states that {u2018}{u2018}SSIs are the third most frequently reported nosocomial infection, accounting for 14% to 16% of all nosocomial infections among hospitalized patients.{u2019}{u2019} In surgical patients, SSIs account for 38% of nosocomial infections.⁽³⁾Rates of SSI are much higher with abdominal surgery than with other types of surgery, with several prospective studies indicating an incidence of 15%{u2013}25% depending on the level of contamination.⁽⁴⁾ The risk of surgical-site infection (SSI) is proportional to the dose and virulence of the infective agent in the wound. Control of SSI at clean operating sites is dependent on the combined efficacy of the disinfection of the skin, and the perioperative antibiotic prophylaxis.⁽⁵⁾ Surgical site disinfection refers to the preoperative treatment of the intact skin of the patient within the operating room. Preparation includes not only the immediate site of the intended surgical incision, but also a broader area of the patient{u2019}s skin, and usually takes place when the patient is already positioned on the operating table.⁽⁶⁾The goal of surgical skin antisepsis, frequently referred to as prepping the skin, is to remove soil and transient (i.e., temporary) microorganisms living on the skin that could pose a risk for SSIs |