الفهرس 
Title :The study of brain derived neurotropic factor level and val66met polymorphism of brain derived neurotropic factor gene in patients with type two diabetes mellitus and depression
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Abstract
Background: Due to ageing, obesity and sedentary lifestyles, type 2 diabetes mellitus (T2DM) is currently affecting around 400 million individuals worldwide and is expected to rise rapidly to be affecting 592 million by 2035. Globally, depression and diabetes represent the 4th and 8th cause of disability adjusted life years, respectively. Depression and distress in T2DM are associated with greater morbidity, mortality and healthcare costs. Like many other chronic conditions, T2DM is associated with depression (Nanayakkara et al., 2018). Individuals with diabetes have a 2{u2013}4 fold greater risk of depression when compared to individuals without diabetes (Badescu et al., 2016). Aim:The current case-control study aimed to evaluate the relation between the levels of BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to finding a relation between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.Subjects and Methods:The current study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders Genotyping was performed by using Real time-PCR-TaqMan probes