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العنوان
Preparation, characterization and biological evaluation of newly formulated nano- radiopharmaceuticals /
الناشر
Dina Mohammed Elsayed Ali Elsafoury ,
المؤلف
Dina Mohammed Elsayed Ali Elsafoury
هيئة الاعداد
باحث / Dina Mohammed Elsayed Ali Elsafoury
مشرف / Doaa Ahmed Elsetouhy
مشرف / Omneya Mohamed Khowesah
مشرف / Mohamed Abdelmotaleb
تاريخ النشر
2021
عدد الصفحات
133 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
5/9/2020
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutics
الفهرس
Only 14 pages are availabe for public view

from 182

from 182

Abstract

The cancer treatment is a very complex process. One of the main obstacles to conventional chemotherapy is finding a technology to deliver the anticancer agents to the cancer tissues in a specific and controlled manner in order to eliminate cancer cells while keeping healthy cells intact. Nanocarriers (e.g., gold nanoparticles, AuNPs) can deliver them to tumor site at a lower dose and in a controlled manner to overcome the side effects of conventional chemotherapy and increase their therapeutic efficiency. Nuclear medicine has the ability to evaluate not only the anatomy of the target site but also its physiological function and biochemical changes in disease states through molecular imaging techniques (e.g., SPECT and PET). Radiopharmaceutical consists of two main compartments, in addition to radioisotope there is a biologically active molecule that binds with the radioisotope so that they can be directed correctly to the desired site of action.Thus, the combination of nuclear medicine (radiopharmaceuticals) and nanotechnology (AuNPs) achieves an efficient and safe delivery of drugs and radioisotopes to the target organ with minimal exposure to non-target tissues and this can be achieved through nanoradiopharmaceuticals design. Nanoradiopharmaceuticals are considered as new class of therapeutic and / or diagnostic agents with great potential in biomedical applications.The potentiality of nanoradiopharmaceutical in tumor diagnosis and/or treatment are based on radioisotopes{u00B4} decay mode, emission properties and physical half-life