الفهرس 
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Abstract
Ischemic kidney injury has been linked to both chronic and acute renal injury in several investigations. The goal of this study was to compare the effects of various ischemia times on kidney function & morphological recovery, as well as to compare the tolerance of paired partial nephrectomy & solitary kidneys to renal ischemia.
Two main groups were studied (N=18), group (1) was used to generate a solitary kidney with open right nephrectomy, while group (2) was used to create a paired kidney model (N=18).
The two groups were again subdivided into three subgroups depending on the renal ischemia time as follows: 30, 60 and 90 min.
Differences between groups were evaluated biochemically using glomerular filtration rate (GFR) and histopathologically by H&E and MT. Immunohistochemical evaluation of apoptosis (by CD95) and renal cell proliferation and regeneration (by PCNA) were also done.
Findings in this study showed that the higher the renal ischemia duration, the higher the impairment in both paired and solitary kidney.
The serum creatinine increase and GFR reduction of ischemic group were correlated with increasing the duration of ischemia length. In consistent, histopathological examination exposed tubular necrosis and tubulointerstitial destruction in ischemic kidney which is proportional with the duration of ischemia.
Apoptosis and necrosis of renal tubules with dilatation and atrophy of renal tubules were the main complication noted in ischemic kidney. Furthermore, the expression of both CD95 and PCNA were significantly increased in kidney tissues with increasing the ischemia time.