الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
There are several safety and health issues associated with the textile industry that involve exposure to fibers dust, chemicals, noise, heat, and ergonomic hazards. Concerning the chemical exposure, the workers engaged in the activities of dyeing, printing, and finishing unit, are specifically usually exposed to a huge source of countless chemical substances like dyes, bleaching agents, optical brighteners, softening agents, and other auxiliary substances. The Aim of this study:- This work aimed to assess the mutagenic risk of chemical exposure among textile dyeing workers in Dakahlia governorate. Subjects and methods:- A comparative cross-sectional study was conducted in the dyeing units of the three medium-scale textile factories in Dakahlia Governorate, Egypt, in the period from the first of May 2018 till the end of April 2020. through identifying occupational exposures by observation of the industrial processes during walk through survey using a standardized score, describing major health problems associated with textile chemicals exposure at dyeing/printing/finishing units, assessing biochemical parameters (urinalysis, CBC, liver, and kidney function), investigating cytokinesis-block micronucleus assay as mutagenic risk biomarker, evaluating DNA repair gene polymorphism as an individual DNA repair capacity biomarker, and exploring the differentially expressed plasma protein fractions as a biomarker for diverse health effects. Results:- Regarding the CBMN-Cyt assay biomarkers, the present study result showed that the mean nuclear division index, as a cytostatic DNA damage effect biomarker, was significantly lower among textile dyeing workers than among the comparison group suggesting a toxic mutagenic effect. In addition, an increase in the mean of biomarkers of genotoxic DNA damage effect was observed among textile dyeing workers when compared to the comparison group (MNi, NPB, and Nbud) signifying a lethal DNA injury. Discussion:- The present study confirming the previous study an increase in the mean±SD biomarkers of genotoxic DNA damage effect among textile dyeing workers when compared to the comparison group; MNi, NPB, Nbud. This reflects sustained mutagenesis in peripheral blood lymphocytes due to the presence of several mutagenic components to which workers are exposed. Conclusion and recommendation:- These findings highlight the importance of workplace assessments and the value of improvements in work conditions. In addition, periodic medical examination, as well as monitoring of blood parameters, can give an insight into certain subclinical health impairments. Moreover, routinely investigating cytokinesis-block micronucleus assay as mutagenic risk biomarker.