الفهرس 
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Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is one of the ubiquitous pollutants worldwide. Thus, the extent of the deleterious impact of DEHP exposure in the last few years has been investigated extensively. To date, the potential thyroid-disrupting effect of DEHP is a matter of scientific interest among different researchers. One of the most proposed mechanisms explaining DEHP-induced thyroid disruption is the induction of oxidative stress.
With the emergence of the nanomedicine era, selenium nanoparticles (Se-NPs) and curcumin nanoparticles (CUR-NPs) have been widely investigated and showed promising antioxidant activities.
Therefore, the present study was conducted to clarify the potential thyroid disrupting effect of DEHP and to explore the probable ameliorative effects of Se-NPs and CUR-NPs against this disruption.
In the present study, physicochemical characterization of the prepared nanoparticles was performed using Transmission Electron Microscopy (TEM) and Nano Zetasizer Particle Analyzer. TEM confirmed successful preparation of non-aggregated Se-NPs and CUR-NPs within the size range of (40–70 nm) and (35–55 nm), respectively. The Zeta potentials of Se-NPs and CUR-NPs were (-14.2 mV) and (-11.3 mV), respectively. Also, the hydrodynamic sizes of Se-NPs and CUR-NPs in deionized water suspension were (95.22 nm) and (98.31 nm), respectively. In addition, the polydispersity index (PDI) of Se-NPs and CUR-NPs was 0.555 and 0.786, respectively.
The present study was carried out on forty-eight adult male albino rats randomly divided into eight groups (6 rats/ group). All chemicals were administered through oral route. There were four control groups; group I (negative control) and three positive control groups as follows; group (II): received corn oil; group III: received selenium nanoparticles (Se-NPS); group IV: received curcumin nanoparticles (CUR-NPs). group V is the DEHP-treated group: received DEHP dissolved in corn oil. Three protected groups were as follows; group VI (DEHP+ Se-NPs): received Se-NPs in combination with DEHP; group VII (DEHP+ CUR-NPs): received CUR-NPs alongside DEHP; group VIII (DEHP+ Se-NPs + CUR-NPs): received DEHP with concomitant administration of CUR-NPs in addition to Se-NPs.