الفهرس | Only 14 pages are availabe for public view |
Abstract The tear film is a thin fluid layer providing a smooth surface over the cornea. It is composed of 3 layers: the innermost mucin layer, an aqueous layer, and the outermost lipid layer. Furthermore, the tear film is a complex mix of electrolytes, proteins (lipocalins, lactoferrin, transferrin, defensin, and lysozyme), phospholipids, oligopeptides, glycopeptides, and immunoglobulins. DED is a disease of the tear film and ocular surface, leading to ocular discomforts and pain. Treatment for dry eye includes the use of artificial tears, antiinflammatory drugs, autologous serum, and punctual occlusion. Artificial tears contain carboxy methylcellulose or hyaluronate sodium, carbomerbased lipid-containing artificial tears (CLAT) and act as a lubricating agent at the ocular surface. Artificial tears provide palliative relief of eye irritation in patients with aqueous tear deficiency, but do not treat the underlying inflammation or reverse conjunctival squamous metaplasia in chronic dry eye. Conventional treatments using topical drugs and punctual occlusion are not effective in the treatment of chronic ocular pain in some patients with dry eye. Recently, vitamin D deficiency has been suggested to be a contributory factor in DES. An association between DES and serum 25- hydroxyvitamin D (25(OH) D) concentration has been suggested. It has been reported that vitamin D plays an immuno-modulatory role in innate and adaptive immunity. Vitamin D and the vitamin D receptor (VDR) regulate several genes involved in inflammation, immunity, cellular proliferation, differentiation, and apoptosis. However, the effect of vitamin D supplementation on dry eye has not been reported. study aimed to investigate the efficacy of topical carbomerbased lipid-containing artificial tears (CLAT) and hyaluronate (HU) in patients with dry eye disease (DED) based on serum 25-hydroxyvitamin D (25HD) levels and cholecalciferol (vitamin D). To elucidate our aim, this was a non-randomized clinical trial study was conducted on 42 patients with DED by Schirmer tear secretion test (mm) who were examined by ophthalmology department, Menoufia university hospital, Egypt. |