الفهرس 
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Abstract
The SUMMARY
Cisplatin [cisdiamminedichloroplatinum (II), CDDP] is a well- known chemotherapeutic drug used for the treatment of numerous human cancer in solid organs, including head and neck, testis, small cells and non-small cells lung cancer, ovarian, cervical and bladder.
Regarding the treatment of cancer cells, CIS is potentially accompanied by some side effects such as ototoxicity, gastrotoxicity, neurotoxicity, myelosuppression, and allergic reactions, the main limiting side effect of CIS use is nephrotoxicity
In view of this concept, this work was conducted in an aim to study the effect of chronic administration of 7-HC on hepato-and nephrotoxicity induced by intraperitoneal injection of cisplatin.
Thirty-six adult male albino rats of a local strain will be used in this study. And obtained from experimental animal laboratory of faculty of science, Beni-Suef University. They will be housed in plastic well aerated cages with meshed floor at room temperature with the natural dark and light cycle, provided with commercial pelleted rodent food, and drunk water ad libitum. They will be kept under observation for about 15 days before the onset of the experiment to exclude any intercurrent infection. Each group (six rats) were housed in cage with dimensions of 25 x 50 x 75 cm. All animals received care according to ethical guidelines of Beni-Suef University. Animals will be subdivided into 6 equal groups as follows:
• group I (control group): fed for 2 weeks on a standard laboratory rat diet offered ad lib.
• group II: fed for 2 weeks on a standard laboratory rat diet and oral administration of 7-HC 100mg/kg.
• group III: fed for 2 weeks on a standard laboratory rat diet and are intraperitoneally injected with single dose of Cisplatin dissolved in normal saline (7 mg/kg) at day 16 (Yilmaz et al., 2004).
• group IV: fed for 2 weeks on a standard laboratory rat and 7-HC is given orally in dose of 25 mg/kg and are intraperitoneally injected with single dose of Cisplatin dissolved in normal saline (7 mg/kg) at day 16 (Yilmaz et al., 2004) .
• group V: fed for 2 weeks on a standard laboratory rat and 7-HC is given orally in dose of 50 mg/kg and are intraperitoneally injected with single dose of Cisplatin dissolved in normal saline (7 mg/kg) at day 16 (Yilmaz et al., 2004).
• group VI: fed for 2 weeks on a standard laboratory rat and 7-HC is given orally in dose of100 mg/kg and are intraperitoneally injected with single dose of Cisplatin dissolved in normal saline (7 mg/kg) at day 16 (Yilmaz et al., 2004).
Significant decrease in apoptosis and apoptotic factors in 7-HC administered rats compared with the results of control group,and increasing in antioxidant factors also decreasing oxidative stress in rats injected with cisplatin.