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العنوان
Correlation between Severity of Liver Disease According to CHILD & MELD Scores and Degree of Cardiac Impairment /
المؤلف
Darwish, Nahed Abd El-Monem.
هيئة الاعداد
باحث / ناهد عبد المنعم درويش
مشرف / نهي عبد الرازق النقيب
مشرف / جورج صفوت رياض
مشرف / جينا جمال نجيب
تاريخ النشر
2021.
عدد الصفحات
171 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الجهاز الهضمي
تاريخ الإجازة
1/1/2021
مكان الإجازة
جامعة عين شمس - كلية الطب - امراض الباطنة، أمراض الجهاز الهضمي والكبد
الفهرس
Only 14 pages are availabe for public view

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from 171

Abstract

Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. The prevalence of cirrhosis has nearly doubled over the last decade, and the number of hospitalizations has similarly increased.
Liver cirrhosis has a high impact on public healthcare, representing an important cause of mortality worldwide. Cardiac complications are not rare during decompensated liver cirrhosis, including diastolic and systolic dysfunction and cardiac electrophysiological remodeling, known as cirrhotic cardiomyopathy. Cardiac complications of liver cirrhosis are typically the result of medications, hemodynamic disorders, infections, inflammatory states, and other unknown factors
Some patients with liver cirrhosis develop a progressive cardiac dysfunction, a condition named cirrhotic cardiomyopathy, that consists of an impaired ventricular performance to different stressful conditions, and may not be clinically significant at rest because of the high cardiac output and low systemic vascular resistance, both present in late stages of liver cirrhosis.
Cirrhotic cardiomyopathy may have a prevalence of up to 60%. It is present in both adult and paediatric patients with cirrhosis and a major cause for morbidity and mortality
A better understanding of pathophysiology and molecular targets will help guide the development of drug therapy for cirrhotic cardiomyopathy.
The aim of work of the current study was to detect correlation between severity of liver disease according to Child and MELD scores and degree of cardiac impairment such as systolic and diastolic functions and ECG changes. To elucidate this aim 60 cases were included in the current study.
In the studied group, the mean age was 58.27 ± 8.38years with about two third of them (75%) were females.
The median MELD. Score was 7.5, the distribution of CHILD. Score was 63.3% A, 23.3% B, 13.3% C. there were 65%, 33.3% had positive ECHO, ECG respectively.
There was statistically significant increase in MELD score, AST, T. bilirubin, D. bilirubin, PT, INR and creatinine level in child C than B and in B than A and also statistically significant decrease in the level of albumin, NA and K.
There was statistically significant relation found between child score and ECG results while no statistically significant relation found with Echo results.
There was a high statistically significant difference in between ECHO and MELD.S, T.Billirubin, D.Billirubin, Creatinine.
In the current study, there was statistically significant increase in age of positive ECG cases than negative ECG cases; also the percentage of males in positive ECG cases was found higher than those of negative ECG cases
There was statistically significant increase in child B and C in positive ECG group than negative ECG group. There was statistically significant increase in the level of Meld score, T. bilirubin and D. bilirubin in positive ECG group than negative ECG group; and statistically significant decrease in the level of albumin and NA in positive ECG group than negative ECG group.
That there was statistically significant positive correlation found between MELD score and AST, ALT, total biliruibn, direct bilirubin, PT, INR and creatinine and also negative correlation found between meld score and albumin and NA levels.