الفهرس | Only 14 pages are availabe for public view |
Abstract Vitiligo is an acquired idiopathic depigmenting skin and mucous membranes that are characterized by well-circumscribed, depigmented macules, and patches that occur secondary to selective destruction of melanocytes. Vitiligo affects about 0.5% to 2% of the world’s population without difference of race or sex. Pathogenesis of Vitiligo is considered to be a multifactorial and polygenic disease caused by the destruction of melanocytes. S100B is a member of calcium-binding protein which is expressed in melanocytes, astrocytes, oligodendrocytes, neural progenitor cells, Schwann cells, kidney epithelial cells, adipocytes, skeletal myofibers, Langerhans cells, and a subpopulation of lymphocytes. It acts as a stimulator of cell proliferation, migration, an inhibitor of apoptosis and differentiation. This study aims to evaluate the correlation between serum level of S100B and Vitiligo activity. . The patients were selected from the outpatient clinic in dermatology and STDs department in Faculty of Medicine, Menoufia University in the period from December 2019 till March 2020. Informed consents were obtained from parents of all participants. The study was approved by the local ethics committee on research involving human subjects, Faculty of Medicine, Menoufia University.Our study is a case-control study that included 60 patients with Vitiligo who were diagnosed with clinical evaluation and 30 healthy individuals as a control group. There were no |