الفهرس 
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Abstract
This study was conducted to assess the burden of exposure to Aluminum on serum level of Aluminum and amyloid precursor protein, and on MMSE for early detection of any deviation from normal regarding cognitive functions for better prognosis among aluminum exposed workers. This was achieved by assessing the relation between serum level of aluminum and both the impairment of cognitive functions and amyloid precursor protein and between this latter and the impairment of cognitive functions.
The study was conducted in the Arab Aluminum Company in Ismailia governorate using a cross-sectional analytic design on 65 workers. All participants were apparently healthy literate males and fulfilling the eligibility criteria. The objectives of the study were achieved through:
a) Structured interview questionnaire to assess socio-demographic data, occupational and medical history.
b) Laboratory investigations including the assessment of serum concentration of Aluminum by graphite furnace atomic absorption spectrophotometry and Serum Amyloid Precursor Protein level by APP Human Elisa Assay.
c) Neuropsychological testing: Mini Mental State Examination (MMSE).
This study revealed that the mean serum concentrations among the studied workers were 1.156 1.49 mg/l for Aluminum levels, 2574.23 935.64 pg/ml for Amyloid Precursor Protein levels and 27.92 1.78 for the MMSE score. Most studied workers had elevated serum Al levels