الفهرس 
Introduction and aim of the studyOnly 14 pages are availabe for public view
 |  | from | 152 |  |  |
| | | from | 152 | | |
Abstract
Background: Visual assessment of wall motion abnormalities (WMA) by 2-
dimensional echocardiography (2DE) is the most semi-quantitative method used
to detect coronary artery disease (CAD), but it carries many limitations. Speckle
tracking echocardiography (STE) overcomes these limitations and allows an
objective quantification of myocardial deformation. Speckle Tracking
Echocardiography (STE) is a new non-invasive method, which has been recently
used as an alternative technique to assess regional and global myocardial
function, especially left ventricular function. It is also considered to be a valid
technique to evaluate the patients with Acute Coronary Syndrome (ACS).
Objectives: The aim of this study to examine the accuracy of global and
segmental longitudinal strain (LS) for the detection of CAD compared with
visual assessment of WMA in acute coronary syndrome patients using coronary
angiography as a golden standard.
Methods: The study enrolled 100 patients (mean age 58.3 ± 10.3, 56% are
male) referred to coronary angiography with clinical suspicion of ACS.2DE
assessment of WMA and evaluation of LS using STE were performed using left
ventricular 17-segments models. Significant CAD was defined as ≥ 70%
stenosis in one or more major coronary arteries by angiography.
Results: According to severity of lesion patients were classified into a group
with lesion more than 70% included 74(74%) patients and a group with lesion
less than 70% included 26(26%) patients. We found that the optimal cutoff
value of GLS was 15.9 for predicting lesion more than 70%. The sensitivity,
specificity of mean GLS versus WMSI were (88.1% & 90.2%) vs (68.5% vs
68.3%), respectively for predicting lesion more than 70%.
Conclusion: Global longitudinal strain (GLS) has higher sensitivity, specificity
and diagnostic accuracy for the detection of severity of lesion, number of vessel
affected than WMSI. GLS can also predict culprit artery affected.
KEY WORDS: Acute coronary syndrome, Speckle tracking, Global
longitudinal strain, Wall motion score index.