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العنوان
Design, Synthesis, and Biological Evaluation of Heterocyclic Compounds as Protease Inhibitors /
المؤلف
Akob, Asmaa Mohamed Atta.
هيئة الاعداد
مشرف / Asmaa Mohamed Atta Akob
مشرف / Samia M. Mostafa
مشرف / Mohamed A. Helal
مشرف / Mohamed S. Elgawish
الموضوع
Medicinal chemistry. Protease inhibitors.
تاريخ النشر
2021.
عدد الصفحات
140 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
1/1/2021
مكان الإجازة
جامعة قناة السويس - كلية الصيدلة - الكيمياء الطبية
الفهرس
Only 14 pages are availabe for public view

from 140

from 140

Abstract

The present thesis consists of the following chapters:
Chapter 1: An introduction about Alzheimer’s disease, protease enzyme, β-secretase and literature review.
Chapter 2: Our rationale is based on design of novel compounds as β-secretase inhibitors using isocytosine, indole and benzimidazoles scaffolds.
Chapter 3: Design of novel compounds, biological evaluation and docking studies.
Chapter 4: Synthesis and characterization of 49 intermediates and 33 final compounds.
References: A list of 169 references used according to their order in thesis.
Appendix: The 13C- NMR and/or 1H-NMR of all the synthesized compounds for this work