الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Background: Evaluation of the role of diffusion-weighted imaging (DWI) in differentiation between benign and malignant soft tissue masses with addition to non malignant tumor-like lesions. Aim of Study: To assess the diagnostic accuracy and the efficacy of DWI and apparent diffusion coefficient (ADC) in assessment of musculoskeletal soft tissue masses with particular regard to the differentiation between benign and malignant soft tissue masses with pathologic correlation. Material and Methods: This study included 57 patients (33 males and 24 females) with musculoskeletal lesions: 24 cases were benign masses, 22 cases were malignant masses and 11 cases were non malignant tumor like lesions according to their histopathological assessment, their ages ranged between 2 and 77 years. Conventional T2- weighted, pre- and post contrast T1-weighted and DW-MRI images with b values 0, 500, 1000 s/mm2 were obtained with corresponding ADC values. The mean ADC values of all lesions were recorded. Results were compared and correlated with final histopathological results. The Inclusion criteria included: Patients with known or suspected to have musculoskeletal soft tissue masses. A minimum scanned soft tissue masses diameter of 1 ” ” ” " ~ " ” ” ” 1.5 cm. The Exclusion criteria included: Patient with metallic medical prosthesis that not MRI compatible including: cardiac pacemaker. Patient refused the examination or claustrophobic patients. Patients with disturbed renal function with GFR < 30 mL/min/1.73m2. Results: As regard our study, patients were categorized into three groups: group (A) patients with benign musculoskeletal masses, and group (B) for patients with malignant musculoskeletal masses, with additional (C) group of non malignant tumor-like lesions were also included. As regard the musculoskeletal masses included in our study a cutoff value of 1.26×10ˉ³ mm²/s was considered to be the threshold for differentiating benign from malignant masses, the sensitivity and specificity were 90.9% and 94.4%, respectively. Conclusion: DWI combined with ADC values of musculoskeletal pathologies showing promising results in differentiating benign from malignant masses.