الفهرس | Only 14 pages are availabe for public view |
Abstract from the past decades cisplatin was one of the important antineoplastic drugs to recover solid tumors such as neck, tests, ovaries, and small cells lung cancer, lymphomas, stomach, esophagus, pancreas, and bladder. Cisplatin faces restriction of usage due to its dangerous side effects like nephrotoxicity, hepatotoxicity, cardiotoxicity, and bone marrow effects. Nephrotoxicity one of the most harmful side effects of cisplatin. Kidney accumulated cisplatin higher than other organs, while a cisplatin concentration in proximal tubules is five-time serum concentration. Furthermore, renal cells uptake cisplatin by active and passive transport. |