الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Liver, which is the body’s second largest organ, performs many essential functions including detoxification, protein synthesis, and the production of biochemicals essential for the nourishment of life. Therefore, patients with chronic liver diseases such as viral hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC) need immediate attention to sustain life (Mishra et al., 2013)There are two distinct inlets provide blood to the liver that including oxygenated blood via the hepatic artery and nutrient-rich blood via the hepatic portal vein. These blood vessels split into tiny capillaries, and the sinusoids of the liver which leading to lobules. Parenchymal hepatocytes occupy 80 percent of the liver, whereas nonparenchymal cells such as sinusoidal endothelial cells (SECs), Kupffer cells (KCs) and hepatic stellate cells (HSCs) constitute 2.8 percent, 2.1 percent, and 1.4 percent, respectively. The hexagonal lobules consist of hepatocyte plates and are cornered by the portal triad consisting of arterioles, venules, and the bile duct. The hepatocyte plates are segregated from the sinusoid liver through the space found in Disse. Space of Disse has the components of the extracellular matrix such as glycosaminoglycans and collagens which may influence the elasticity of the fenestrated blood vessel wall and the rate of exchange of substrates (Böttger et al., 2020) . Dynamic endothelial fenestrations spanning approximately 50–200 nm as shown in Figure (1, 2 ,3) (Mishra et al., 2018).