الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The solvency/dissolution conduct of active drug substance is the most key determinant to its oral bioavailability, it is viewed as the rate-restricting step for absorption of the medicament from the gastrointestinal tract and consequently to the blood circulation. In recent pharmaceutical technologies, discovering of new drugs can be performed by innovation of combinatorial chemistry and high throughput screening, which represents good pharmacological activities. However, a lot of recent drugs suffer from low aqueous solubility, the bioavailability of lipophilic drugs is a predominant challenge that faces the progress of many pharmaceuti-cal dosage forms, especially oral ones. In consequence of the limited aqueous solubility of such drugs, bad dissolution profile and erratic bioavailability are usually accompanying those drugs, so promotion of drug dissolution and conse-quently its oral bioavailability remains the utmost important step in developing of new pharmaceutical products. Various methods have been devolved to overwhelm the solubility prob-lem of hydrophobic drugs such as, for example, formation of self-emulsifying drug delivery systems, formation of inclusion complexes, reduction of the parti-cle size by micronization or nanonization. These techniques take into considera-tion the actual active ingredients’ properties and the chosen excipients’ proper-ties. Solid dispersion as a method used to promote the dissolution pattern of hydrophobic drugs, has been utilized for long time, and it remains the most proper and cost-effective way for enhancing drug solubility.