الفهرس 
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Abstract
Perioperative hearing loss occurs more frequently than most anaesthesiologists suspect. Much Concern has been raised about the effects of anaesthetic drugs on cognition. Postoperative cognitive dysfunction may manifest as impairment in attention, memory, language or executive functions following surgery, and can persist for weeks, months, or more with varying severity.
This study was conducted to detect the possible deleterious effect of propfol versus sevoflurane on auditory and cognitive function (attention and auditory memory). A total of 80 patients were enrolled in this study (n = 40 in each group). In group (1), patients received maintenance Propofol total intra venous anaesthesia (TIVA) 6-12 mg/kg/hr. by syring pump , 100% O2. In group (2), patients received maintenance of Sevoflurane 1.5-2% ,100% O2.
Auditory function was assessed for the included patients before and 1 week after the operation using the auditory brainstem response. Cognitive function was assessed for the included patients before and 1 week after the operation using PALT and PASAT
There was no statistically significant difference between Propofol group and Sevoflurane group regarding median B/P, HR, SPO2 or ETCO2.
In Propofol group, the median values for LTABR-I, and LTABR-III after operation were significantly higher than before operation and the median values for RTABR-I, RTABR-III, RTABR-V, RTABR I-III, RTABR I-V, and RTABR III-V after operation were significantly higher than before operation.
In Sevoflurane group, the median values for LTABR-I, and LTABR-III after operation were significantly higher than before operation and the median values for RTABR-III, RTABR-V, RTABR I-III, and RTABR III-V after operation were significantly higher than before operation
There was no statistically significant difference between propofol and Sevoflurane groups regarding ABR parameters.
Regarding cognitive assessment, the median value for PASAT (which assess attention and auditory working memory) after operation was significantly lower than before operation in both Propofol group and Sevoflurane group with no significant difference between the two groups.
In Propofol group, the median value for PALT (which assess auditory verbal memory), after operation was significantly lower than before operation. However, in Sevoflurane group, there was no significant difference between the median value of PALT before and after operation. There was a statistically significant difference between the two groups regarding PALT.
Conclusion:
There were significant postoperative hearing loss and impairment in attention and auditory memory following propofol and Sevoflurane anaesthesia with no significant difference between the two groups.