الفهرس | Only 14 pages are availabe for public view |
Abstract Liver cirrhosis and H.Pylori infection are two common diseases in our population and reducing the incidence of complications in cirrhotic subjects is an important step in current gastroenterology practice, early diagnosis and effective prevention of complications and its contributing factors will help in reducing mortality and morbidity in these patients, so considering the role of H.Pylori infection in cirrhosis related complications (Zhou et al.,2014). The aim of the present study is to determine incidence of H. Pylori infection among patients with liver cirrhosis secondary to HCV infection and study the correlation between esophageal varices degree and H. Pylori infection. This study involved 50 patients with liver cirrhosis secondary to Hepatitis C Virus infection were selected from gastroenterology and internal medicine clinics and departments at Beni-Suef general hospital. Our results illustrate that the percent of H. pylori infection among studied patients was 68%. Our results illustrate that no significant association between age and H. pylori detection while male gender, higher weight, hypertensive, diabetic and patients with GIT upset were associated with positive H. pylori detection and these association were significant p value (0.004, 0.014, 0.001 and 0.003) respectively. Our results illustrate that there is statistically significant association between the grade of varices and the detection of H. pylori; p value is less than 0.001 Our results demonstrated that there is a significant correlation between leucocytic count and albumin and detection of H. pylori. The odds of H pylori detection is 2.2 times higher in case of increased leucocytic count Conclusion H. pylori infection is significantly frequent among patients with liver cirrhosis secondary to HCV infection. The incidence of esophageal varices correlates with the incidence of H. pylori infection. Limitation of the study First, this was single- center , descriptive study. Therefore we could not detect causal relationship and the generalization of our results should be with caution. Second, the sample size used in the present study was smaller than that of the studies that showed significant relationship between liver cirrhosis and H. pylori infection . Third, need to follow up patients after eradication of H.pylori infection. |