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Abstract Gene of 16s rRNA is an important component factor of the transcription process of all DNA-dependable life organisms. It represents a target gene for DNA sequencing in samples that contain more than thousands of different species. This gene helps in discrimination among specific different microorganisms as archaea, bacteria, and microbial eukarya. However the identification of viruses needs sequencing of metagenom (it is a direct DNA extracted sequencing from a community of microorganisms) as their deficiency of the phylogenetic marker of 16S rRNA gene. This work aimed to study the possible association of gut microbiota 16S rRNA target region with obesity. The abundant gut microbiota in lean, obese, and obese with DM subjects. Obesity is defined as a medical state that happen when a person has an excessive body weight or fat that may affect his health status. An obese person has a high body mass index, which is a tool used to recognize if a person has an ideal weight for his age, sex, and height. Normal BMI is from (18.5-24.9). Persons with BMI (25-29.9) are considered overweight. BMI is more than or equal 30 is classified as obese. There are other measures to detect the obesity like the, BF%, and fat distribution all over the body involved to determine healthy obesity and non-healthy one. Numerous studies have demonstrated a link between microbiota and obesity. Obese subjects show reduced richness and diversity of GM, with an alteration in the specific pattern of the main phyla found in humans and rodents. Gut microbiome has an important role on the following four broad areas which are corner stones of human health: Nutrition, Immunity, Behavior, and Diseases. |