الفهرس 
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Abstract
Summary and Conclusion
Iron oxide NPs are used in medicine and biology as selective carriers of drugs to organs, as cancer cell killers and also, as a contrast material in magnetic resonance tomography. The most in vivo Nano toxicities from magnetic iron oxide nanoparticles arise from the production of excess reactive oxygen species (ROS). Antioxidant effect of Calotropis procera extract have been demonstrated in different studies.
The experiment had been carried out on 80 albino rats. The animals randomly divided into equal 4 groups. The first group served as control, the second group treated by oral doses of Calotropis procera Arial parts extract (500 mg/kg Bw daily), the third group treated by magnetic iron oxide nanoparticle (50 mg/kg Bw orally daily), the forth group treated by magnetic iron oxide nanoparticle and oral dose of Calotropis procera Arial parts extract daily for 4 weeks respectively. Blood samples obtained for biochemical analysis of liver functions and cardiac enzymes. Neurotransmitters were measured in brain homogenate. Oxidative stress biomarkers levels were determined in the brain, liver, and heart homogenates. Histopathological examination of the brain, liver, and heart was conducted through hematoxylin-eosin staining.
Our data showed that administration of CP extract with MIONPs co- treatment decrease the levels of ALT, AST, Alkaline phosphatase, CK-MB, Troponin Ι, and MDA level in liver and brain homogenates that were increased in MIONPs group. It increase the other oxidative biomarkers (SOD, CAT and GPx) in different tissue homogenate. It decrease the levels of glutamate and dopamine in brain tissue homogenate which were increased in MIONPs treated group. Brain, Liver, and heart histological sections show degeneration, necrosis, congestion, and inflammatory cells infiltration. CP extract supplement group showed a degree of improvement in brain, liver and heart.
Conclusion:
Calotropis procera extract supplementation has a protective effect on MIONPs-induced oxidative stress, biochemical and histopathological changes in Brain, liver and heart.