الفهرس 
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Abstract
The fungicide IPR and the insecticide CPF are concurrently applied for early disease control in fruits and other crops. There is cumulative evidence that IPR and CPF are endocrine disruptors that can evoke reproductive toxicity. Eighty male albino rats (immature and mature). Immature (3-4 weeks) weighing 60-70 g and mature (10-12 weeks) weighing 180–240g were obtained from the Animal House of the Faculty of Veterinary Medicine, Zagazig University, Egypt. The rats were housed in plastic cages placed in a well-ventilated rat house, provided rat feed and water ad libitum and subjected to natural photoperiod of 12h light/12h dark cycle. The experiment was carried out in compliance with the institutional guidelines for the care and use of experimental animals approved by The Institutional Animal Care and Use Committee Zagazig University with approval number ZU-IACUC/2/ F/41/2019.
Rats were randomly divided into two main groups (immature and mature). Each group divided into four subgroups of ten rats each. Control group: orally administered corn oil (1 ml/rat). IPR group: orally received 200 mg/kg b.wt (1/20 LD50). CPF group: orally received 7.45 mg/kg b.wt (1/20 LD50) and co-exposure group: orally received 200 mg/kg b.wt. IPR and 7.45 mg/kg b.wt. CPF. The treatments were given orally using gastric gavage from PND 23 to PND 60 in immature groups and for 65 days in mature group.