الفهرس 
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Abstract
The aim of this study was to evaluate serum adiponectin level in
obese patients with gastroesophageal reflux disease and barrett’s
esophagus.
This study was conducted on 120 participants included 60
patients with GERD, 30 patients with Barrett esophagus as well as, 30
participants of matched age and sex as controls. All participants were
selected with BMI ≥25. Patients and controls were selected from
Tropical Medicine department Menoufia university hospital and
Shebin El-kom Teaching hospital in period between October 2018 to
April 2020. Patients were 48 males (53.3%) and 42 females (46.7%).
Their ages were ranging between 27 – 64 years old. Also, control
group was 17 males (56.7%) and 13 females (43.3%).
Informed consent was obtained from all participants in
accordance with local ethical committee.
Patients and controls were classified in to the following groups:
group (I): Included thirty obese persons without GERD as control.
group (II): Included sixty obese patients with GERD.
group (III): Included thirty obese patients with Barrett esophagus.
All subjects were subjected to the following: Full history
taking, physical examinations and laboratory investigation with
measurement of serum adiponectin by ELISA, upper GI endoscopy
and histopathological examination for biopsies taken from query
barrett lesions.
Statistical analysis of the presenting data revealed:
• In the present study no statistically significant difference between
groups as regard age and gender, also, regarding smoking as special
habit most of patients in group (ІІ) and group (ІІІ) in comparison
with control group (І) are smokers.
• In present study fasting blood glucose was higher in group (II) than
group (III) with statistically signifigant difference between the three
studied groups which means that obese patients are more liable to
develop GERD and diabetes mellitus as a part of metabolic
syndrome.
• In present study no statistically significant diffrernce between the
three studied groups regarding different anthropometric
measurements, BMI and midarm circumference. While, there was
statistically significant diffrernce between the three studied groups
regarding waist/hip ratio.
• In present study no statistically significant difference between the
three studied groups regarding hemoglobin concentration, white
blood cell count, platelets count, ALT, AST as well as, no
statistically significant difference regarding total cholesterol and
triglycerides.
• Regarding lipid profile, this study showed a significant increase in
serum cholesterol and triglycerides in all groups which means that
obese patients are more liable to develop GERD and dyslipidemia
as a part of metabolic syndrome.
• Also, in our study we found an inverse relationship between plasma
adiponectin and serum triglyceride levels as well as, fasting plasma
glucose concentrations.