الفهرس 
Introduction
Glutamate in peripheral tissuesOnly 14 pages are availabe for public view
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Abstract
MSG is the sodium salt of the glutamic acid, it is a food additive applied to shield flavour and improve the taste. Glutamate is an example of the abundant amino acids in nature and is the chief ingredient of various proteins and peptides of greatest tissues. Glutamate is additionally offered in the body and performs a vital purpose in human metabolism as glutamate receptors have been expressed in the central nervous system, liver, kidney, spleen, lung, pancreas and testicle. The Food and Drug Administration (FDA) stated that MSG is safe as a flavor enhancer; however, its safety as a food additive remains debated. MSG has been linked to several metabolic disordes in several experimental models and high doses of MSG in fetal and small rodents increased body weight and fat mass and can also damage organs such as liver, brain and kidney. Studies have also demonstrated glutamate-induced oxidative damage in tissues like brain and kidneys, where α-ketoglutarate dehydrogenase, glutamate receptors and cysteine-glutamate antiporter are the vital players. Based on this background, the aim of our study was to Evaluate the possible metabolic abnormalities that could develop as result of MSG administration in a dose close to the usual doses taken in diet. Investigate MSG-induced structural and functional changes in both liver and kidneys. Illustrate whether these changes could be affected by the age of animals at the time of administration of MSG either at the neonatal or at adulthood periods. Forty male Wistar albino rats were used in the study design. They were randomly divided into 4 groups.